Jak se v medicíně připravujeme na svět 4.0?

prof. MUDr. Vladimír Mihál, CSc.

Urol. praxi. 2018;19(2):53  

Effectiveness and safety of abiraterone acetate treatment for metastatic castration-resistant prostate cancer post-chemotherapy

MUDr. Tomáš Hradec, FEBU, MUDr. Otakar Čapoun, FEBU

Urol. praxi. 2018;19(2):61-63 | DOI: 10.36290/uro.2018.057  

Castration resistant prostate cancer (CRPC) is an advanced stage of this disease with a significant impact on patients quality of lifeand unfavourable prognosis. Docetaxel chemotherapy is considered a standart treatment. Further treatment options in case ofdisease progression after chemotherapy are very limited. Cytochrome P-450 c17 inhibitor, abiraterone acetate (AA) is a novel drugused in second line treatment of CRPC. In this article we present results of international clinical studies evaluating efficiency andsafety of AA treatment. According to these studies AA together with prednisone significantly improves median overall survival,time to prostate-specific...

Syndrome of chronic scrotal pain (part one)

doc. MUDr. Jozef Marenčák, PhD.

Urol. praxi. 2018;19(2):64-67 | DOI: 10.36290/uro.2018.058  

Idiopathic scrotal pain syndrome (SPS) is defined as at least 3 months of chronic or intermittent scrotal content pain. SPS remainsone of the more challenging urological problems to manage. This can be a frustrating process for both the patient and clinicianas there is no well – recognized diagnostic regimen or reliable effective treatment. Many of these patients will end up seeingphysicians across many disciplines, further frustrating them. The etiology of SPS is not clearly delineated. Expected mechanismsinclude damage to the scrotal and spermatic cord nerve structures via inflammatory effects of the immune system, back pressureeffects in the...

Nocturia – will the urologist handle it?

MUDr. Libuše Vilhelmová

Urol. praxi. 2018;19(2):68-71 | DOI: 10.36290/uro.2018.059  

Nocturia is a very troublesome symptom; its incidence in the population is high and increases with age. For its significant impacton the quality of life of patients it is often the first reason to visit the urology department. Due to the complexity of the etiopathogenesisof this disease, the urologist's main role is the careful diagnosis. Integral part is the evaluation of the so-called frequencyvolume chart. Depending on the etiological type of nocturia (polyuria, nocturnal polyuria, reduced bladder capacity or sleepdisorders) treatment is initiated. Regulation of fluid intake and treatment of primary illness are indicated regardless of the typeof...

Proton-beam therapy controversies in prostate cancor

prof. MUDr. Jiří Petera, Ph.D., doc. MUDr. Miloš Broďák, Ph.D., MUDr. Jan Pokorný, FEBU, MBA, MUDr. Michaela Matoušková, Vlasta Králová

Urol. praxi. 2018;19(2):72-75 | DOI: 10.36290/uro.2018.060  

The authors describe the possibilities of radiotherapy of prostate cancer and focus on certain controversies associated withproton therapy in this indication. They bring up to date published data on the results and risks associated with proton therapyin prostate irradiation. The work also contains presented case studies of patients with proton-related complications who havebeen or are being treated for urology.

Current treatment options for cancer pain

MUDr. Jan Lejčko

Urol. praxi. 2018;19(2):76-80 | DOI: 10.36290/uro.2018.061  

The treatment of cancer pain is an important part of a comprehensive oncological approach. Pharmacotherapy with strongopioids is of crucial importance. The currently available opioid agents, including opioids for the control of breakthrough pain,allow for appropriate individualization of pain management. The use of additional, more recent options of pharmacotherapy,such as cannabinoids, adjuvant analgesics, antidepressants, and local treatment agents, can contribute to improving the qualityof analgesia. In the case of refractory pain, interventional pain treatment procedures can be beneficial. Continuous treatmentmonitoring and multidisciplinary collaboration...

Oncofertility – perspectives and complications

doc. MUDr. Igor Crha, CSc., prof. MUDr. Martin Huser, Ph.D., MBA, doc. RNDr. Jana Žáková, Ph.D.

Urol. praxi. 2018;19(2):81-85  

Current assisted reproduction techniques can be used to protect reproductive functions of oncological patients. The key factorstowards successful clinical implementation of these methods are good awareness and collaboration between clinical oncologistsand the assisted reproduction center with established reproductive protection program including surgical interventions onovaries and testes. Sperm cryopreservation represents the basic technique to protect the reproduction of men. The recognizedfertility preservation methods available for women are ovarian suppression with gonadoliberine analogues, ovarian stimulationwith oocytes and embryos collection...

Prostatitis – practical notes to diagnostics and treatment

MUDr. Martina Poršová, MUDr. Ivan Kolombo, FEBU, MUDr. Jaroslav Porš

Urol. praxi. 2018;19(2):86-88  

We use term „prostatic syndrome“ instead of the term „prostatitis“ recently. Ethiological agent can be found in only five to tenpercent of all cases. European Association of Urology recommends classification suggested by NIDDK/NIH (National Institute ofDiabetes, Digestive and Kidney Diseases/National Institutes of Health). Diagnosis of this syndrome is based on symptomatologyand presence of leukocytes and ethiological agent in the prostate and in its secretions. Treatment of the most patients is empirical.

Rare causes of gross hematuria in childhood

MUDr. Jan Starczewski

Urol. praxi. 2018;19(2):89-92 | DOI: 10.36290/uro.2018.037  

Gross hematuria is usually a disturbing finding for both the affected child and their parents. This occurrence involves fast diagnosticevaluation of hematuria causes. We present four children with symptoms of acute gross hematuria with rare findings inchildhood such as bladder stones and benign tumors of lower urinary tract.

Urethroplasty according to Mathieu as a treatment option for iatrogenic urethral fistula

MUDr. Pavel Kříž, MUDr. Khaled Baker, MUDr. Vojtěch Mezera, Ph.D., MUDr. Ivo Novák, Ph.D.

Urol. praxi. 2018;19(2):93-94 | DOI: 10.36290/uro.2018.064  

The aim of our work is to present a case report, where a successful Mathieu's urethroplasty and meato-glanduloplasty were performedfor a urethral fistula which was created as a complication of frenuloplasty.

Nurses' intention to leave the profession

Mgr. Jana Heczková, prof. MUDr. et Mgr. Alan Bulava, Ph.D.

Urol. praxi. 2018;19(2):95-98 | DOI: 10.36290/uro.2018.065  

The shortage of healthcare workers is currently considered a serious global problem. This could be further escalated due to theexpected demographic changes in the future. Finding a solution how to prevent qualified and experienced nurses from leavingtheir profession may be critical. Currently available evidence suggests that the main reason for a decision to leave nursing maynot only be the level of remuneration or individual characteristics of nurses, but above all a large number of factors affecting thequality of work environment. Those factors influence not only the increasing nursing turnover but also affect negatively the qualityof the provided...