Urolog. pro Praxi, 2011; 12(1): 12-17

Practical approach to a patient with bone metastases in urological malignacies

MUDr.Milan Král, Ph.D., MUDr.Martin Hrabec, MUDr.Michal Grepl, Ph.D., doc.MUDr.Vladimír Študent, Ph.D.

Urologická klinika LF UP a FN Olomouc

Skeletal involvement is one of the most serious topics in diagnostics and therapy of metastatic urooncological malignancies. It is a complex

process affecting normal osteogenesis which has as a consequence onset of skeletal pain, anemia due to involvement of red bone

marrow by neoplastic cells and their factors. The main danger is instability of axial skeleton with increased risk of pathological fractures

and related spinal cord compression. In this review we present current diagnostical and therapeutic options in patients with skeletal

metastasis. Besides specific approaches in prevention and therapy of bone metastasis (analgotherapy, radiation therapy, therapy with

isotopes, bisphosphonates, surgery and novel drugs) also non-specific approaches play important role (vitamin D supplementation, calcium

and physical activity). The severity of skeletal changes in oncourology is cause usually due to insufficient clinical response and this

is the challenge for further clinical research in near future.

Keywords: bone metastasis, therapy, cancer, radiation, bisphosphonates.

Published: February 25, 2011  Show citation