Síla křehkosti

Martina Špinková

Urol. praxi, 2014; 15(5): 203  

Immunotherapy in prostate cancer

MUDr.Kateřina Kubáčková

Urol. praxi, 2014; 15(5): 208-210  

The immunotherapy based on progress in tumour immunology became a part of intensive research as a novel strategy in cancer treatment. Sipuleucel-T is the first and only medicinal product approved by the regulatory agencies in USA and Europe for the treatment of asymptomatic or minimal symptomatic castrate- refractory prostate cancer. It represents the first product of autollogous cell therapy. This article gives a brief overview about new approaches in the cancer immunotherapy in clinical development.

Urogynaecological infections: the perspective of a urogynaecologist

doc.MUDr.Jaromír Mašata, CSc.

Urol. praxi, 2014; 15(5): 211-216  

Vulvovaginal infections are among the most common problems encountered in routine everyday gynaecological practice. Urologists often require collaboration with gynaecologists in the case of women with recurrent urinary tract infections when they need to rule out chronic vulvovaginal infection as a cause of the complaints. Most patients with vulvovaginal infection only require a simple examination and treatment. Nevertheless, in a proportion of women it is difficult to establish the correct diagnosis or they respond poorly to standard therapy. Classic manifestations of infections include discharge, itching or burning of the vulva. The conditions...

Arterial hypertension and benign prostatic hyperplasia are specific aging men diseases.

MUDr.Petr Hušek, MUDr.Jaroslav Pacovský, Ph.D., MUDr.Lukáš Holub, MUDr.Josef Košina, doc.MUDr.Miloš Broďák, Ph.D.

Urol. praxi, 2014; 15(5): 219-220  

Adrenergic nervous system plays main role in both cases pathogenesis. The specific receptors blocking in the target tissues decreases adrenergic control of the smooth muscles localized in prostate and arterial wall. It makes positive effect as in the bladder neck obstruction as the arterial hypertension. Alpha receptors blockers, primary developed for the arterial hypertension treatment, are the first choice medicament therapy of benign prostate hyperplasia at present. Alpha receptors blockers can be used for uncontrolled arterial hypertension therapy in combination with other drugs only, not in monotherapy.

Possible causes of incontinence and their solutions

MUDr.Miroslava Romžová

Urol. praxi, 2014; 15(5): 221-226  

Urinary incontinence is a condition that can occur in both sexes, regardless of age. Their formation is involved in many other well defined disease. A thorough diagnosis is essential for the correct identification of the type of incontinence and successful therapy.

Impaired spermatic venous drainage, varicocele and preventive-predictive medicine. Update, or new paradigma?

MUDr.Vladimír Kubíček, CSc.

Urol. praxi, 2014; 15(5): 227-229  

Many studies suggest association of the impaired venous drainage and varicocele not only with male infertility. Association of the varicocele with testosterone deficiency was probably first time described by Stárka and Raboch in 1971. Several current studies confirm improvement of serum testosterone level after varicocelectomy, several studies confirm association of the varicocele with erectile dysfunction and premature ejaculation. Generaly used EAU guidelines are insufficient in this point; there is necessary to create a new paradigm for the diagnosis and treatment of the impaired spermatic venous drainage and varicocele. Preventive, predictive...

Priapism for line of first contact

MUDr.Zdeněk Mucha, MUDr.Pavel Rajmon, MUDr.Filip Čtvrtlík, Ph.D.

Urol. praxi, 2014; 15(5): 230-234  

Information about the incidence, etiology, diagnostics and therapy The authors propose basic data on the issue of priapism problematics to the public, such as to whom an individual can turn for a help. It does not have to be always a urologist. The report would like to be a basic source of information about the seriousness of the illmess as well as abouth the need for a prompt urologic solution. It is aimed to a broad public (partners, friends and family menbers). There is no use of seeking help at general practitioners, emergency doctors or other related fields. These always correctly pass an ill person to urologic clinics. The proposed...

Urothelial papilloma of the renal pelvis in a young man

MUDr.Jan Zaplatílek, MUDr.Kamil Belej, Ph.D., FEBU, Mgr.Jiří Janota, MUDr.Ivana Peisarová, MUDr.Richard Pabišta

Urol. praxi, 2014; 15(5): 235-236  

The authors report a case of recurrent macroscopic haematuria in a young man. Ureterorenoscopy showed an exophytic tumour of the renal pelvis; cold biopsy was performed and urothelial papilloma was confirmed histologically. A preserving procedure was indicated which involved laser ablation of a residual benign tumour performed with a flexible ureterorenoscope. The outcome of the management chosen was a clear benefit for the patient including complete preservation of renal function.

Paratesticular cystadenoma with ovarian stroma

MUDr.Radka Bulínová, MUDr.Pavel Holan, MUDr.Leoš Handrejch, MUDr.Marek Koch, MUDr.Jiří Ladman

Urol. praxi, 2014; 15(5): 237-238  

In the following article we present a case report dealing with the case initially recognized paratesticular cystadenoma with ovarian stroma of epithelial tumors of group paratesticular tissue. This is the first recorded case in our department. Due to very sporadic occurrence of these tumors certainly deserves publication and is good on the possible occurrence of these rare tumors know.

Fournier’s gangrene in patient with new diagnosed rectal tumor infiltrating prostate

MUDr.Andrej Kolodzej, MUDr.Martin Novák

Urol. praxi, 2014; 15(5): 239-240  

This case report presents patient with a new diagnosed rectal tumor, which was detected during the urological examination in our office. The patient was reffered to specialists included surgeon, oncologist and gastroenterologist to complete the diagnostics and start treatment. Unfortunately patient‘s performance status and urological complications averted him from curative treatment. We present management of following urological complications – acute incomplete retention of urine, prostate abscess and extensive Fournier‘s gangrene.

Urinary incontinence after radical prostatectomy

Mgr.Nataša Sochorová, Josefa Ďulíková, MUDr.Eva Burešová

Urol. praxi, 2014; 15(5): 244-245  

Prostate cancer is among the most commonly occurring malignant tumours in men, accounting for approximately 16% of all malignancies in men over 50 years of age. In the case of localized disease, radical retropubic prostatectomy (RRP) or robot-assisted radical prostatectomy (RARP) are indicated. This treatment may have permanent sequelae for the patient (e.g., urinary incontinence or erectile dysfunction).

Zpráva z jednání SAU v Brně 29. 11. 2014

doc.MUDr.Miroslav Hanuš, CSc., MUDr.Michaela Matoušková

Urol. praxi, 2014; 15(5): 246  

Urinary dysfunction in patients with multiple sclerosis

MUDr.Eva Burešová, MUDr.Aleš Vidlář, Ph.D.

Urol. praxi, 2014; 15(5): 241-243  

Multiple sclerosis is a systemic autoimmune disease of the central nervous system (CNS) with a typical onset in young adulthood, most frequently between the ages of 20 and 40 years. Women are affected twice as often as men. The pathogenesis involves autoimmune mechanisms. Chronic inflammation can attack any part of the CNS, but most commonly the cerebral cortex and the spinal cord. Neurological deficiency is manifested by a wide spectrum of clinical problems, including voiding dysfunctions.