Urol. praxi, 2015; 16(4): 148-150

Fosfomycin trometamol: re-established antibiotic in urology

MUDr.Miroslav Fajfr, Ph.D.¹, MUDr.Miroslav Louda, Ph.D.², MUDr.Pavla Paterová¹, MUDr.Lenka Ryšková, Ph.D.¹

¹ Ústav klinické mikrobiologie FN, Hradec Králové

² Urologická klinika FN, Hradec Králové

From October 2014 there has been available a „new“ per oral antibiotic for urinary tract infection in the Czech Republic - fosfomycin

trometamol. This antibiotic, first described in 1969, is very effective to common urogenital pathogens include Gram positive cocci, but

also to Gram negative bacteria with extended spectrum beta lactamase production. The study from Faculty hospital Hradec Králové

confirms high susceptibility (78.9–97.0 %) of tested urological pathogens (Escherichia coli, Klebsiella pneumoniae, Proteus sp., Enterobacter

sp.). But from the literature there is well known the rapid resistance increase after the fosfomycin wide use Fosfomycin trometamol

should be earmarked for the therapy of strains that are proven to nitrofurantoin insensitive and in particular strains of bacteria with the

production of beta lactamase.

Keywords: fosfomycin, urinary tract infection, treatment indication

Published: November 1, 2015  Show citation