Urol. praxi. 2025;26(3):119-124 | DOI: 10.36290/uro.2025.067
Urinary tract infections 2.0: How to tackle multidrug-resistant bacteria
- Klinika infekčních nemocí a cestovní medicíny 2. LF UK a FN Motol, Praha
Urinary tract infections (UTIs) are among the most common bacterial infections in both community and hospital care. UTIs are primarily caused by gram-negative bacteria, which have shown a significant increase in antibiotic resistance in recent years, particularly to beta-lactams. This resistance is mainly due to the production of various beta-lactamases, with the most significant being carbapenemases. The article provides an overview of current knowledge on different types of beta-lactam resistance and presents information on newly available beta-lactams that can overcome some of these resistance mechanisms. It also includes a practical approach to the treatment of UTIs caused by multidrug-resistant bacteria.
Keywords: urinary tract infections, antibiotics, resistence, carbapenemases.
Accepted: September 29, 2025; Published: October 17, 2025 Show citation
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